In 1999 “Way Home” formed Department of “HIV / AIDS” that made the beginning of development and implementation of first preventative HIV program in Ukraine among injecting drug users, based on principals of harm reduction strategies. Gradually the scope of Department’s activities were expanded – new directions were added in work, such as prevention of viral hepatitis B and C, tuberculosis prevention, working with inmates in prisons, organized outreach work, social support, legal assistance. For injecting drug users were opened Community Centre, stationary and mobile NSPs (needle exchange points) started to work, mobile clinic begun its visits to drug users points, where express testing for HIV are realized, as same as for hepatitis and tuberculosis, all this allow to make medical check-ups in outdoor environments, in addition to it, Ukrainian delivery of social periodicals were spread along the city. Over time, work of “HIV / AIDS” Department of “Way Home” set up their work not only in the city but also out of Odessa. Various branches were opened in regional center of Odessa oblast, such as – Ilyichevsk, Izmail and Belgorod-Dniester. Also Department specialists work in remote settlements of region, where drug use is on a high level, social and health services are very poor. Since 1999 and until now, “HIV / AIDS” Department were reach service coverage to more than 13,500 of injecting drug users and their partners, providing an access to more than 30 types of services, affecting the change of risk behavior.